Recent trends in next generation immunoinformatics harnessed for universal coronavirus vaccine designReview Published on 2023-03-012023-07-09 Journal: Pathogens and global health [Category] COVID19(2023년), [키워드] characterization database Epitope prediction Human coronavirus immunoinformatics peptide vaccine vaccine target. [DOI] 10.1080/20477724.2022.2072456 PMC 바로가기 [Article Type] Review
Genetic analysis and biological characterization of H10N3 influenza A viruses isolated in China from 2014 to 2021Article Published on 2023-02-012023-06-22 Journal: Journal of medical virology [Category] 조류인플루엔자, [키워드] characterization genesis H10N3 reassortant Transmission. [DOI] 10.1002/jmv.28476 PMC 바로가기
Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화Article Published on 2022-12-012022-09-11 Journal: Virulence [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] aggravation ameliorated anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Antiviral antiviral activity cationic caused cell lines characterization cholesterol complex Compound compounds COVID-19 pandemic COVID-19 patient cytopathic Cytopathic effect Drug discovery effective envelope envelope proteins epiandrosterone followed by hACE2 HEK293 host cell host cells identification in vitro in vivo indicated inhibited initial involved life Lipid mechanism membrane modulate modulation Mortality Pathogenesis progeny protective effect Protective effects Proteins Quality of life reduce reduce COVID-19 aggravation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selected Selection single mutation single mutations specific treatment spike steroidal compounds. subversion Transgenic mouse translate transmembrane Treatment treatment of COVID-19 patients Vero Vero CCL81 cell Vero CCL81 cells viral replication Viral RNA viral variant Viral variants [DOI] 10.1080/21505594.2022.2085793 PMC 바로가기 [Article Type] Article
A Characterization and an Evolutionary and a Pathogenicity Analysis of Reassortment H3N2 Avian Influenza Virus in South China in 2019-2020Article Published on 2022-11-212023-06-22 Journal: Viruses [Category] 조류인플루엔자, [키워드] Avian influenza virus characterization Evolutionary H3N2 mice pathogenicity potential threat Reassortment strong virulence. [DOI] 10.3390/v14112574 PMC 바로가기
Characterization and immunogenicity of SARS-CoV-2 spike proteins with varied glycosylationArticle Published on 2022-11-082022-11-15 Journal: Vaccine [Category] SARS, 진단, [키워드] 293 cells 293F cell acute respiratory syndrome addition binding caused Cell changed characterization convalescent sera coronavirus Coronavirus disease-19 COVID-19 Critical discrepancy effective Efficacy elicited exhibited expression globe glycosylated glycosylation glycosylation pattern homogeneity host cells IgG immunization immunogenicity insect cell mammalian cells mice Neutralizing antibody response neutralizing antibody titre pandemic Protein Proteins provide reactivity Receptor binding regimen robust S protein S-2P SARS-CoV-2 SARS-CoV-2 spike protein spike Spike. the S protein thermal stability Vaccine Vaccine design Variation virus virus entry while [DOI] 10.1016/j.vaccine.2022.09.057 PMC 바로가기
Biochemical Characterization of Emerging SARS-CoV-2 Nsp15 Endoribonuclease VariantsArticle Published on 2022-10-302022-11-16 Journal: Journal of Molecular Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Affect analysis analyzed biochemically bioinformatics catalytic caused changed characterization characterized cleavage Combination conserved coronavirus Coronaviruses Course COVID-19 pandemic domain drug design effort endoribonuclease endoribonuclease. EndoU evade Evolution facilitate Genome help Host immune response in vivo inactive increase in innate immune response middle monomeric Mutation N-terminal nonstructural proteins novel coronavirus SARS-CoV-2 Nsp15 oligomerization pandemic Patient prevalent Protein residue RNA SARS-CoV-2 SARS-CoV-2 sequence Sequencing Transcription triggering understanding variant viral genome Viral protein viral replication virus wild type [DOI] 10.1016/j.jmb.2022.167796 PMC 바로가기
Characterization of Casirivimab Plus Imdevimab, Sotrovimab, and Bamlanivimab Plus Etesevimab-Derived Interference in Serum Protein Electrophoresis and Immunofixation ElectrophoresisArticle Published on 2022-10-292022-11-15 Journal: The journal of applied laboratory medicine [Category] 진단, [키워드] added antibody assay interference B-cell bamlanivimab Casirivimab Cell characterization COVID-19 diagnostic Electrophoresis etesevimab evaluate evaluated Imdevimab Immunofixation immunofixation electrophoresis in vitro infused Interference medication monoclonal monoclonal antibody monoclonal antibody therapy neoplasm Patient patients plasma platform producing recognizing serum Serum protein serum protein electrophoresis. serum sample serum samples Sotrovimab sustained tested therapeutic [DOI] 10.1093/jalm/jfac064 PMC 바로가기
Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological PerspectiveArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] (S)-Goniothalamin Anti-viral anticancer antioxidant antiviral properties antiviral property approach characterization complex Compound coronavirus COVID-19 derivation derivative disease drug examined LC-MS molecular molecular dynamics MPro NMR pandemic performed phytochemical platform Pro RdRP required Research SARS-CoV-2 SARS-COV-2 infection Simulation study spike glycoprotein spike glycoprotein. target target protein threat [DOI] 10.3390/molecules27206962 PMC 바로가기
Systematic analysis and comparison of O-glycosylation of five recombinant spike proteins in β-coronavirusesArticle Published on 2022-10-162022-11-15 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis antiviral drug Biological functions cell entry characterization characterized Coronavirus-2 D614G domains FIVE functional glycosylated help less membrane fusion mutant N-glycosylation O-glycosylation Recombinant spike protein S proteins S1 protein S1 subunit SARS-CoV-2 Sialylation spike Spike protein Spike proteins Vaccine β-coronavirus β-coronavirus β-coronavirus. β-CoV β-CoVs [DOI] 10.1016/j.aca.2022.340394 PMC 바로가기
NVX-CoV2373 vaccination induces functional SARS-CoV-2-specific CD4+ and CD8+ T cell responsesArticle Published on 2022-10-032022-11-15 Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adaptive immunity CD4+ CD4+ T cell CD4+ T cells CD8+ T cell Cell Cellular immune response characteristic characterization circulating correlated COVID-19 demonstrated detectable dose Efficacy follicular full-length SARS-CoV-2 functional humoral immune responses IFN-γ immune immunization immunology individual induce magnitude Matrix-M NVX-CoV2373 Protective Protein response responses robust SARS-CoV-2-neutralizing antibody spike trimer subset T cells T cells. Th1 cell trials vaccinated individual vaccination Vaccine [DOI] 10.1172/JCI160898 PMC 바로가기